- Title
- Does dietary fat cause a dose dependent glycemic response in youth with type 1 diabetes?
- Creator
- O'Connell, Susan M.; O'Toole, Nora M. A.; Cronin, Conor N.; Saat-Murphy, Chen; McElduff, Patrick; King, Bruce R.; Smart, Carmel E.; Shafat, Amir
- Relation
- Pediatric Diabetes Vol. 22, Issue 8, p. 1108-1114
- Publisher Link
- http://dx.doi.org/10.1111/pedi.13273
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2021
- Description
- Objective: To determine the glycemic impact of dietary fat alone consumed without prandial insulin in individuals with T1D. Research Design and Methods: Thirty participants with T1D (aged 8–18 years) consumed a test drink with either 20 g glucose or 1, 13, 26, 39, 51 g of fat with negligible carbohydrate/protein on 6 consecutive evenings, in a randomized order without insulin. Continuous glucose monitoring was used to measure glucose levels for 8 h postprandially. Primary outcome was mean glycemic excursion at each 30 min interval for each test condition. Generalized linear mixed models with a random effect for people with diabetes were used to test for an increase in blood glucose excursion with increasing quantity of fat. Results: Glycemic excursions after 20 g glucose were higher than after fat drinks over the first 2 h (p < 0.05). Glycemic excursion for the fat drinks demonstrated a dose response, statistically significant from 4 h (p = 0.026), such that increasing loads of fat caused a proportionally larger increase in glycemic excursion, remaining statistically significant until 8 h (p < 0.05). Overall, for every 10 g fat added to the drink, glucose concentrations rose by a mean of 0.28 mmol L−1 from 330 min (95% CI 0.15 to 0.39, p < 0.001). Conclusions: Fat ingested without other macronutrients increases glucose excursions from 4 to 8 h after ingestion, in a dose dependent manner. These observations may impact on insulin dosing for high-fat foods in individuals with T1D.
- Subject
- dietary fat; gastric emptying; insulin dosing; insulin resistance; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1472742
- Identifier
- uon:48914
- Identifier
- ISSN:1399-543X
- Language
- eng
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